教育经历
2014-09至2019-07，首都医科大学，神经生物学系，博士研究生，导师：杨慧 2009-09至2014-07，首都医科大学，基础医学，本科，导师：杨慧
2014-09至2019-07，Capital Medical University，neurobiology，PhD candidate，Supervisor：Hui Yang 2009-09至2014-07，Capital Medical University，Basic Medicine，Undergraduate，Supervisor：Hui Yang
工作经历
2019-08至现在, 首都医科大学, 北京脑重大疾病研究院, 副教授
2019-08 until now, Capital Medical University, Beijing Institute of Brain Disorders, Associate Professor
研究概述
现研究方向为低氧参与神经损伤的分子机制研究。主要关注：①低氧诱导全身各脏器损伤的器官及细胞异质性；②低氧诱导神经元退变的分子机制；③间歇性低氧适应的神经保护作用。描述了低氧适应在神经系统疾病中的保护作用和机制（CNS Neurosci Ther，2021）。发现单体药物PLG和PIP通过激活线粒体自噬而抵抗细胞凋亡，在帕金森病模型中发挥神经保护作用（Autophagy, 2018; Oncotarget, 2016），提出以BCL-2家族蛋白为靶点调节自噬-凋亡再平衡是抵抗神经退变的干预策略（ACS Chemical Neuroscience, 2018）。发现帕金森病相关蛋白PINK1与α-synuclein的相互作用结构域，揭示了PINK1发挥神经保护作用的机制（Cell Death and Disease, 2017），提出靶向线粒体自噬而干预神经退变的重要性（Cells, 2019）。
Our current researches focus on the molecular mechanism of hypoxia involved in nerve injury. The main concerns are as follows: ① organ and cell heterogeneity in hypoxia induced injury; ② molecular mechanism of neuronal degeneration induced by hypoxia; ③ neuroprotective effects and molecular mechanism of intermittent hypoxia conditioning. We described the protective effects and mechanisms of hypoxic adaptation in neurological diseases (CNS Neurosci Ther, 2021). We found PLG and PIP resist apoptosis by activating mitochondrial Autophagy and play neuroprotective roles in Parkinson's disease models (Autophagy, 2018; Oncotarget, 2016), suggesting that targeting Bcl-2 family proteins modulates autophagy-apoptotic rebalancing as an intervention strategy against neurodegeneration (ACS Chemical Neuroscience, 2018). We found the interaction domain of PINK1 and α-synuclein, revealing the mechanism of PINK1 mediated neuroprotective effects (Cell Death and Disease, 2017), and proposing the importance of targeting mitochondrial autophagy to intervene in neurodegeneration (Cells, 2019).
代表成果
一、发表文章 ①. Liu J#, Gu Y, Guo M, Ji X*; Neuroprotective effects and mechanisms of ischemic/hypoxic preconditioning on neurological diseases. CNS Neurosci Ther, 2021, 27(8):869-882. ②. Li R, Lu Y, Zhang Q, Liu W, Yang R, Jiao J, Liu J, Gao G, Yang H*. (2021). Piperine promotes autophagy flux by P2RX4 activation in SNCA/α-synuclein-induced Parkinson disease model. Autophagy, 1-17. ③. Liu J, Liu W, Li R, Yang H*. (2019). Mitophagy in Parkinson’s disease: from pathogenesis to treatment. Cells, 8(7). pii: E712. ④. Liu J, Liu W, Lu Y, Tian H, Duan C, Lu L, Gao G, Wu X, Wang X, Yang H*. (2018). Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models. Autophagy, 14(5):845-861. ⑤. Liu J, Liu W, Yang H*. (2018). Balancing apoptosis and autophagy for Parkinson’s disease therapy: targeting BCL-2. ACS Chemical Neuroscience, 10(2):792-802. ⑥. Tian H, Lu Y, Liu J, Liu W, Lu L, Duan C, Gao G, Yang H*. (2018). Leucine Carboxyl Methyltransferase Downregulation and Protein Phosphatase Methylesterase Upregulation Contribute Toward the Inhibition of Protein Phosphatase 2A by α-Synuclein. Front Aging Neurosci, 10: 173. ⑦. Yang W#, Wang X#, Liu J#, Duan C, Gao G, Lu L, Yu S, Yang H*. (2018). PINK1 suppresses alpha-synuclein-induced neuronal injury: a novel mechanism in protein phosphatase 2A activation. Oncotarget, 9(1): 37-53. ⑧. Liu J#, Wang X#, Lu Y, Duan C, Gao G, Lu L, Yang H*. (2017). Pink1 interacts with alpha-synuclein and abrogates alpha-synuclein-induced neurotoxicity by activating autophagy. Cell Death Dis, 8(9): e3056. ⑨. Chen M, Liu J, Lu Y, Duan C, Lu L, Gao G, Chan P, Yu S, Yang H*. (2017). Age-dependent alpha-synuclein accumulation is correlated with elevation of mitochondrial TRPC3 in the brains of monkeys and mice. J Neural Transm (Vienna), 124(4): 441-453. ⑩. Liu J, Chen M, Wang X, Wang Y, Duan C, Gao G, Lu L, Wu X, Wang X, Yang H*. (2016). Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson's disease model. Oncotarget, 7(38): 60823-60843.
二、其它学术成就 ① 中国神经科学学会神经科学技术分会，委员，2020/10-至今 Neuroscience and Technology of Chinese Neuroscience Society, committee member，2020/10 until now ② 中国神经科学学会神经退行性疾病分会，委员，2020/10-至今 Neurodegenerative disease of Chinese Neuroscience Society, committee member，2020/10 until now ③ CNS Neurosciences & Therapeutics (SCI)期刊，编委，2019/12-至今 CNS Neurosciences & Therapeutics, editorial board member，2019/12 until now ④ 中国神经修复学会，青年委员，2019/12-至今 Chinese Nerve Repair Society，Youth committee member，2019/12 until now ⑤ 第十五届张锡钧基金全国青年优秀生理学学术论文，中国生理学会，2019 The 15th Zhang Xijun Foundation National Youth Excellent Physiology Academic Research，Chinese Physiological Society，2019 ⑥ 首都医科大学优秀博士论文，首都医科大学，2019 Excellent Doctoral Thesis of Capital Medical University，Capital Medical University，2019 ⑦ 北京市优秀博士毕业生，北京市教育委员会，2019 Outstanding Graduate of Beijing，Beijing Municipal Education Commission，2019 ⑧ 第十九届北京青年学术演讲比赛二等奖，北京市科学技术协会， 2018 Second prize of the 19th Beijing Youth Academic Speech Contest，Beijing Association for Science and Technology，2018
